Exploring New Frontiers in ML as a PhD: Ida Büschel’s Journey from Munich to Northwestern University

Ida Büschel is a postgrad/predoc student in Carsten Marr’s lab at Helmholtz Munich and is currently focussing on the study of twin/sister cell transcriptomes from time- and lineage-resolved single-cell RNA sequencing data for inference of gene co-regulation and detection of transcriptomic signatures of asymmetric fate decisions.
In summer 2024, she joined the lab of Yogesh Goyal at Feinberg School of Medicine at Northwestern University in Chicago, Illinois.
1. How did your visit impact your project?
I only started working on the project upon my arrival in Chicago. Since Yogesh’s lab is half computational half wet-lab/experimental, I greatly benefited from the interdisciplinary exchange. Having a computational background myself (engineering and applied mathematics), I gained a lot of knowledge regarding biological systems, data modalities and experimental design. With Northwestern being one of the top research universities in the US, I had access to numerous expert-led conferences, seminars and lectures, which were equally interesting and inspiring.
2. What are the things you liked the most about your stay at Northwestern University?
I really appreciated the curiosity, ambition, and willingness to help and collaborate within Yogesh’s lab. Being part of such a well-connected, lively, and dynamic research environment was incredibly motivating. I also loved having access to seminars and talks given by both internationally renowned and young, "up-and-coming" scientists - it was a great way to stay inspired, exchange knowledge, and build connections. On a more personal note, the lab’s proximity to Lake Michigan was a dream - just a 10-minute walk to the nearest beach, which was especially fun in summer. Chicago’s diverse ethnic food scene and its rich music culture (especially as the home of house music and Chicago-style blues) were also major highlights.
3. What will you take back from there?
To engage more in conversations and discussions, especially with people from other fields and backgrounds. These exchanges are incredibly valuable for gaining new perspectives and expanding your knowledge and skill set - and that applies as much to personal life as it does to research. I also learned not to be too harsh with myself. Adjusting to a new working environment, city, and country can be challenging, and it’s okay to feel overwhelmed sometimes. Lastly, I realized that the U.S. is a very complex country - sometimes hard to fully grasp as an outsider.
4. How will the project you started at Northwestern continue now that you’re back at Helmholtz?
I will work on it for at least another three months under both Carsten’s and Yogesh’s supervision, hopefully resulting in a publication. Hence, I am still meeting regularly with Carsten, Yogesh and my project partner at Northwestern via Zoom.
5. What would you recommend to other PhD students who want to visit Northwestern University?
Try to visit during summer (at least partially) so you can take full advantage of the lake, beaches, and all the outdoor activities - beach volleyball, Sunday morning club with free open-air Pilates and yoga classes by the lake, food festivals, and more. If you’re there in winter, be prepared! It can get very cold and windy, but Chicagoans are are very resilient and life goes on no matter the weather. Always keep an eye out for free food and drinks - since Northwestern is a private university, most events like lectures, seminars, or departmental celebrations include catering. Also, sign up for relevant mailing lists to stay informed about lectures and seminars - many are really worth attending.
Northwestern is a fast-paced, high-intensity workplace with a strong work ethic centered on commitment, dedication, and responsibility. It’s inspiring to be surrounded by such ambitious and driven people. That said, it’s important to find a pace that works for you and allows you to enjoy life outside academia - if that’s something you value. And definitely take advantage of Chicago’s amazing ethnic food options - Mexican, Indian, Mediterranean, Ethiopian, Ukrainian - try it!
6. Any final words?
Be gentle with yourself and others and always keep an open mind.